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DETECTION OF SPECIFIC ANTIBODY IN SERA OF MICE IMMUNIZED WITH RECOMBINANT SCHISTOSOMA JAPONICUM PARAMYOSIN

Zhou Jin

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Abstract

Objective To explore the mechanism of recombinant Schistosoma japonicum 97 ku protein(rSj97) in inducing protective immunity against S. japonicum . Methods Specific antibody titre and dynamics in sera of mice immunized with rSj97 were detected by ELISA. Results The specific antibody could be deteced after the first immunization, the antibody levels were gradually elevated after the second immunization and reached the peak before challenge. The mean antibody titre before challenge in sera reached 1∶ 51 200 . Conclusion rSj97 could stimulate mice to produce a notoble humoral immunity response.

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What this paper is about

Objective To explore the mechanism of recombinant Schistosoma japonicum 97 ku protein(rSj97) in inducing protective immunity against S. japonicum . Methods Specific antibody titre and dynamics in sera of mice immunized with rSj97 were detected by ELISA. Results The specific antibody could be deteced after the first immunization, the antibody levels were gradually elevated after the second immunization and reached the peak before challenge. The mean antibody titre before challenge in sera reached 1∶ 51 200 . Conclusion rSj97 could stimulate mice to produce a notoble humoral immunity response.

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Available abstract

Objective To explore the mechanism of recombinant Schistosoma japonicum 97 ku protein(rSj97) in inducing protective immunity against S. japonicum . Methods Specific antibody titre and dynamics in sera of mice immunized with rSj97 were detected by ELISA. Results The specific antibody could be deteced after the first immunization, the antibody levels were gradually elevated after the second immunization and reached the peak before challenge. The mean antibody titre before challenge in sera reached 1∶ 51 200 . Conclusion rSj97 could stimulate mice to produce a notoble humoral immunity response.

Key concepts: Schistosoma japonicum, Immunization, Antibody, Recombinant DNA, Humoral immunity, Titer, Biology, Immunity

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