Association study of angiotensin converting enzyme polymorphism with myocardial infarction in Chinese

Objective: To examine the association of angiotensin converting enzyme insertion/deletion (ACE I/D) polymorphism with myocardial infarction in Chinese. Methods: 150 patients were genotyped with myocardial infarction and 150 controls. ACE I/D polymorphism genotyping was performed by using PCR. Data of medical history, and physical examination were also collected. Results: Allele frequencies of I and D alleles were 0.58, 0.42 in myocardial infarction group and 0.65 , 0.35 in controls. The genotype frequencies were in Hardy Weinberg equilibrium. The association of ID or DD genotype with myocardial infarction was not found in the total sample, but an association of DD genotype with myocardial infarction was found in the subpopulation younger than 60 years(OR=2.33,95%CI:1.20 4.57). Furthermore, this association was strengthened in patients of myocardial infarction with obesity.Conclusion: An association of ACE I/D polymorphism with myocardial infarction was found in a subpopulation younger than 60 years, which was strengthened in patients of myocardial infarction with obesity.