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2002•Chinese Journal of Critical Care MedicineRequires access

Relationship between angiotensin-1 converting enzyme gene polymorphism and acute myocardial infarction

Miao Run-fang

Open publisher page 2 citations

Abstract

Objective To expolre the polymorphism of the angiotensin-1 converting enzyme(ACE) gene responsible for acute myocardial infarction.Methods In this study,the patients(n=140)with myocardial infarction and control subjects(n=57) who were matched for established risk factors were consecutively selected.ACE genotypes were characterized by PCR method,and all patients were examined clinical and bio-chemical indexes.Results The ACE-DD genotype was more frequent in the patients with acute myocardial infarction than ID or Ⅱ genotypes (P0 0005),and the D alleles frequency was higher than the I alleles frequency.Conclusion The DD genotype of ACE gene had clear influence on myocardial infarction,and the D alleles substantially increased the incidence of acute myocardial infarction.

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What this paper is about

Objective To expolre the polymorphism of the angiotensin-1 converting enzyme(ACE) gene responsible for acute myocardial infarction.Methods In this study,the patients(n=140)with myocardial infarction and control subjects(n=57) who were matched for established risk factors were consecutively selected.ACE genotypes were characterized by PCR method,and all patients were examined clinical and bio-chemical indexes.Results The ACE-DD genotype was more frequent in the patients with acute myocardial infarction than ID or Ⅱ genotypes (P0 0005),and the D alleles frequency was higher than the I alleles frequency.Conclusion The DD genotype of ACE gene had clear influence on myocardial infarction,and the D alleles substantially increased the incidence of acute myocardial infarction.

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Available abstract

Objective To expolre the polymorphism of the angiotensin-1 converting enzyme(ACE) gene responsible for acute myocardial infarction.Methods In this study,the patients(n=140)with myocardial infarction and control subjects(n=57) who were matched for established risk factors were consecutively selected.ACE genotypes were characterized by PCR method,and all patients were examined clinical and bio-chemical indexes.Results The ACE-DD genotype was more frequent in the patients with acute myocardial infarction than ID or Ⅱ genotypes (P0 0005),and the D alleles frequency was higher than the I alleles frequency.Conclusion The DD genotype of ACE gene had clear influence on myocardial infarction,and the D alleles substantially increased the incidence of acute myocardial infarction.

Key concepts: Medicine, Myocardial infarction, Genotype, Internal medicine, Angiotensin-converting enzyme, Allele, Polymorphism (computer science), Cardiology

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