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2009•Medical Journal of West ChinaRequires access

Immuno-suppression of interfereon-gamma and interleukin-4 in mice with Salmonella Typhimurium infection

Wan Chao-ming

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Abstract

Objective To analysis immuno-suppression of interfereon-gamma and interleukin-4 in mice with Salmonella typhimurium infection.Method 24 BALB/c mice were orally infected with S.Typhimurium by a single dose and divided into 2 groups,including experimental group with immunosuppressive agents(EG) and untreated group(UG),respectively.The spleen,liver and small intestine were pathologically detected with microscope.The interferon-γ(IFN-γ) and interleukin-4(IL-4) of splenocytes were measured with flow cytometry.Result The expression of IL-4 in EG was significantly higher than that in UG.The expression of IFN-γ in EG was significantly lower than that in UG.The pathological lesions in EG were serious compared with that in UG.Conclusion Immunosupperssion may induce excessively Th2 type immunological response to salmonella infection.

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What this paper is about

Objective To analysis immuno-suppression of interfereon-gamma and interleukin-4 in mice with Salmonella typhimurium infection.Method 24 BALB/c mice were orally infected with S.Typhimurium by a single dose and divided into 2 groups,including experimental group with immunosuppressive agents(EG) and untreated group(UG),respectively.The spleen,liver and small intestine were pathologically detected with microscope.The interferon-γ(IFN-γ) and interleukin-4(IL-4) of splenocytes were measured with flow cytometry.Result The expression of IL-4 in EG was significantly higher than that in UG.The expression of IFN-γ in EG was significantly lower than that in UG.The pathological lesions in EG were serious compared with that in UG.Conclusion Immunosupperssion may induce excessively Th2 type immunological response to salmonella infection.

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Available abstract

Objective To analysis immuno-suppression of interfereon-gamma and interleukin-4 in mice with Salmonella typhimurium infection.Method 24 BALB/c mice were orally infected with S.Typhimurium by a single dose and divided into 2 groups,including experimental group with immunosuppressive agents(EG) and untreated group(UG),respectively.The spleen,liver and small intestine were pathologically detected with microscope.The interferon-γ(IFN-γ) and interleukin-4(IL-4) of splenocytes were measured with flow cytometry.Result The expression of IL-4 in EG was significantly higher than that in UG.The expression of IFN-γ in EG was significantly lower than that in UG.The pathological lesions in EG were serious compared with that in UG.Conclusion Immunosupperssion may induce excessively Th2 type immunological response to salmonella infection.

Key concepts: Medicine, Salmonella, Splenocyte, Spleen, Flow cytometry, Salmonella infection, Immunology, Pathological

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Immuno-suppression of interfereon-gamma and interleukin-4 in mice with Salmonella Typhimurium infection — Research Paper | ScholarLens