The Dynamic Change of Kv4.2 Expression in Left Ventricular Hypertrophied Myocardium of Spontaneously Hypertensive Rat

Objective To study the dynamic change of Kv4.2 expression in left ventricular hypertrophied myocardium of sponta-neously hypertensive rat(SHR).Methods Kv4.2 expression was measured in left ventricular myocardium of 10,20 and 30-week SHR by the Western-Blot technique,at the same time,the heart mass index(HMI) and left ventricular mass index(LVMI) were also studied.The 10-week Wistar-Kyoto rat was served as the control group.Results ①The LVMI and HMI of SHR were significantly higher than those of Wistar-Kyoto rat(P0.01).In SHR,the LVMI and HMI were significantly different(P0.01).②The Kv4.2 expression in SHR was signifi cantly lower than that of Wistar-Kyoto rat(P0.01).In SHR,the Kv4.2 expression was significantly different(P0.01).③There was significantly negative relationship between the Kv4.2 expression and LVMI(r=-0.99,P0.01).Conclusion The more significant left ventricular hypertrophy,the lower myocardial Kv4.2 expression.