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2007•Chinese Journal of HypertensionRequires access

Sodium Channel Current In Hypertrophied Myocardiocytes in Spontaneously hypertensive Rat

Wei Yu-li, Sun Yat-sen

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Abstract

Objective To study the change in sodium channel current(ⅠNa)in the developement of the left ventricular hypertrophy in spontaneously hypertensive rat(SHR).Methods ⅠNa and membrane capacitance(MC)were measured in myocytes of 10,24 and 34-week SHR by the whole-cell patch-clamp technique.Systolic blood pressure(SBP)and left ventricular mass index(LVMI)were detemined.10-week old Wistar rats served as controls.Results LVMI and MC of SHR were significantly higher than those of Wistar rat(P0.01).LVMI and MC were significantly different among 3 age groups of SHR(P0.01).The density ofⅠNain 10 and 24-week SHR were of no different from that of 10-week Wistar rat(P0.05),however the density of ⅠNain 34-week SHR were higher than those of Wistar rat(-18.3±1.9)vs(-15.3±2.0)pA/pF,P0.05).The density of ⅠNawas significantly related with LVMI(r=0.879,P0.01).Conclusion The density of ⅠNa in myocytes was associate with the degree of hypertrophy of left ventriele.

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What this paper is about

Objective To study the change in sodium channel current(ⅠNa)in the developement of the left ventricular hypertrophy in spontaneously hypertensive rat(SHR).Methods ⅠNa and membrane capacitance(MC)were measured in myocytes of 10,24 and 34-week SHR by the whole-cell patch-clamp technique.Systolic blood pressure(SBP)and left ventricular mass index(LVMI)were detemined.10-week old Wistar rats served as controls.Results LVMI and MC of SHR were significantly higher than those of Wistar rat(P0.01).LVMI and MC were significantly different among 3 age groups of SHR(P0.01).The density ofⅠNain 10 and 24-week SHR were of no different from that of 10-week Wistar rat(P0.05),however the density of ⅠNain 34-week SHR were higher than those of Wistar rat(-18.3±1.9)vs(-15.3±2.0)pA/pF,P0.05).The density of ⅠNawas significantly related with LVMI(r=0.879,P0.01).Conclusion The density of ⅠNa in myocytes was associate with the degree of hypertrophy of left ventriele.

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Available abstract

Objective To study the change in sodium channel current(ⅠNa)in the developement of the left ventricular hypertrophy in spontaneously hypertensive rat(SHR).Methods ⅠNa and membrane capacitance(MC)were measured in myocytes of 10,24 and 34-week SHR by the whole-cell patch-clamp technique.Systolic blood pressure(SBP)and left ventricular mass index(LVMI)were detemined.10-week old Wistar rats served as controls.Results LVMI and MC of SHR were significantly higher than those of Wistar rat(P0.01).LVMI and MC were significantly different among 3 age groups of SHR(P0.01).The density ofⅠNain 10 and 24-week SHR were of no different from that of 10-week Wistar rat(P0.05),however the density of ⅠNain 34-week SHR were higher than those of Wistar rat(-18.3±1.9)vs(-15.3±2.0)pA/pF,P0.05).The density of ⅠNawas significantly related with LVMI(r=0.879,P0.01).Conclusion The density of ⅠNa in myocytes was associate with the degree of hypertrophy of left ventriele.

Key concepts: Internal medicine, Endocrinology, Muscle hypertrophy, Patch clamp, Sodium channel, Sodium, Spontaneously hypertensive rat, Blood pressure

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