Jian Sun
Abstract
The alkynyl aldehyde-participated direct Mannich reaction was first reported.A series of novel alkyny-containing β-amino ketones were synthesized by the Mannich reaction of aromatic alkynyl aldehydes with ketones and aliphatic amines using Brnsted acid as the catalyst and THF as the solvent.
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The alkynyl aldehyde-participated direct Mannich reaction was first reported.A series of novel alkyny-containing β-amino ketones were synthesized by the Mannich reaction of aromatic alkynyl aldehydes with ketones and aliphatic amines using Brnsted acid as the catalyst and THF as the solvent.
Key concepts: Chemistry, Aldehyde, Mannich reaction, Catalysis, Organic chemistry, Solvent, Brønsted–Lowry acid–base theory, Ketone