Effects of Cilostazol and Nimodipine Combined Therapy on Delayed Cerebral Vasospasm after Subarachnoid Hemorrhage

Objective To discuss the clinical effects of cilostazol and nimodipine combined therapy on cerebroval vasospasm(CVS) after subarachnoid hemorrhage(SAH).Methods Totally 210 patients with intracranial SAH were randomly divided into control group and treatment group.The patients in control group were treated with nimodipine 1 mg/h pumping continuously for 14 days.The patients in the treatment group were given nimodipine 1 mg/h pumping continuously and cilostazol 50 mg twice per day for 14 days.Vital signs were monitored continuously in all patients.The clinical data of pre-and post-therapy in the two groups,such as clinical manifestation,the level of consciousness(GCS grade,Hunt Hess scores),CT,TCD and MRI,were compared.Results There was no significant difference in GCS grade,Hunt Hess,Fisher pre-therapy between the two groups(P 0.05).The incidence of cerebral infarction in the treatment group [11(10.5%)] was lower than that of the control group [23(21.9%)](P 0.05).TCD showed the mean blood flow of median cerebral artery(MCA) was 115.6±12.5 cm/s in control group and 112.5±10.9 cm/s in the treatment group(1 day after hemorrhage),and there was no difference between the two groups(P 0.05).The mean blood flow of MCA on 3,7 and 14 days after hemorrhage in the treatment group was obviously slower than those of the control group(P 0.05).The effective rate of the treatment group(74.3%) was higher than that of the control group(60.0%)(P 0.05).Conclusion The combined therapy of cilostazol and nimodipine was effective for delayed CVS after SAH.