Effects of Different Administrations of Ondansetron on Nausea and Vomiting During Postoperative Laparoscopic Cholaparoscopic

Objective To evalute the prophylactic efficacy of different modes of and ministration of ondansetron on postoperative nausea and vomiting on the laparoscopic cholecystectomy(LC).Methods The 200 patients of American Society Anesthesiologists(ASA)Ⅰ-Ⅱ scheduled for LC were randomly divided into 4 groups with 50 cases each.Before commencement of PAC,the patients received no ondansetron(groupⅠ),ondansetron 8 mg immediately(groupⅡ),ondansetron 4 mg immediately and ondansetron 4 mg in PCA pump(groupIII),and ondansetron 8 mg in PCA pump(groupⅣ).Incidences of nausea and vomiting and side effects were recorded at 2,4,8,20,36,48 h after operation.Results In group Ⅱ,the incidences of nausea and vomiting were reduced significantly compared with thous in group I at 2,4,8 h(P0.05).In group Ⅲ,the incidence of nausea and vomiting were reduced significantly compared with the group Ⅰ at 2,4,8,20,36,48 h(P0.05).In group Ⅲ,the incidences of PONV were reduced compared with the group II at 36,48 h(P0.05).In group Ⅱ,the incidences of PONV were reduced significantly compared with group Ⅳ at 2,4,8 h(P0.05).In group Ⅲ,the incidences of PONV were reduced compared with group Ⅳ at 2,4,8,16,20,36,48 h(P0.05).Conclusion The strategy of intravenous ondansetron 4 mg after the surgery and 4 mg in PCA pump is better than that of intravenous in reducing the incidence of PONV in 48 h.