The investigation of the prophylactic effect of ondansetron on postoperative vomiting after laparoscopic cholecystectomy

Objective To investigate the prophylactic effect of ondansetron on postoperative vomitting after laparoscopic cholecystectomy.Methods Two hudered patients were divided into 5groups randomly,respectively treated with saline 10ml(Ⅰgroup);ondansearon 4mg(Ⅱgroup);ondansetron 4mg+dexamethasone 10mg(Ⅲ group);ondansetron 8mg(Ⅳ group),ondansetron 4mg(befor anesthesia induction)+ondansetron 4mg(after LC)(V group).Make a different record about the degree of PONV on patients after operation 6、12、24h.Results The incidence of PONV on the other 4groups decresase obviously within 24hs,comparing with Ⅰ group,and the incidence of Ⅲ group is lower than Ⅱ,Ⅳand Ⅴ group(P0.05).In addition,there is no comparision and significant difference among Ⅱ group,Ⅳ group and Ⅴ group.Conclusion The prophylactic effect of ondansetron+dexamethasone on PONV is better for less advers reactions and expense.