Effect of Weiyang Shengji Decoction on Refractory Peptic Ulcer

Objective To observe the effect of Weiyang Shengji Decoction(WSD)on refractory peptic ulcer(RPU).Methods Sixty RPU patients were equally randomized into 2 groups.The control group received triple therapy of metronidazole,amoxicillin and omeptazole.The treatment group received WSD(mainly composed of Radix Angelicae Sinensis,Rhizoma Atractylodis Macrocephalae,Poria,Radix Paeoniae Alba,Herba Hedyotis Diffusae,Radix Astragali,powder of Radix Trichosanthis,Radix Curcumae,Fructus Citri Sarcodactylis,Radix Glycyrrhizae,powder of Radix Notoginseng,powder of Rhizoma Bletillae)besides the triple therapy.After treatment for 2 months,the clinical symptoms,gastroscopic results and helicobacter pylori(HP)eradication rate were observed,and the plasma endothelin 1(ET-1)level was detected.Results After treatment for 2 months,the total effective rate was 90.0% in the treatment group and 76.7% in the control group(P0.05);HP eradication rate was 92.9% in the treatment group and 92.6% in the control group(P0.05);the plasma ET-1 level was increased in the two groups(P0.05 or P0.01 compared with that before treatment),and the increase was obvious in the treatment group(P0.05).Conclusion Herbal medicine of WSD can enhance the effect of western medicine for RPU,and its mechanism may be related with the promotion of ET-1 formation.