Fas associated phosphatase-1 expression in the cerebral cortex and hippocampus after focal cerebral ischemia in rats

Objective To study the expression of Fas associated phosphatase-1(FAP-1)in cerebral cortex and hippocampus after cerebral ischemia in rats.Methods The distribution and quantity of FAP-1 immunological positive cells in the brain were observed with immunohistochemistry method after focal ischemia.Results The number of FAP-1 positive cells in cerebral cortex and hippocampal gyrus of cerebral ischemia rats were 10.76±1.23 and 9.24±0.87,obviously higher than sham operation group(4.12±0.36,3.83±0.43)(all P0.001).FAP-1 immunological stained zone was mainly distributed in the dendrite and axon of cortical pyramidal cells,which was supplied by middle cerebral artery.Conclusions FAP-1 in cerebal tissue of cerebral ischemic rats is over expression.It can show ischemic damage of brain.