Study on expression of β-APP in neurons of hippocampus after cerebral ischemia in human

Objective To observe the expression of β-amyloid precursor protein in neurons of hippocampus CA1 and CA3 regions after cerebral ischemia in human.Methods The neuronal damage was examined by using of HE staining,and the expression of β-APP was determined with immunohistochemistry in the hippocampal CA1 and CA3 regions in control group and 2～6h,7h～1d,2d～,3d～,4d～,5～6d and 7d～ groups after cerebral ischemia.β-APP positive cells were counted in five microscopic fields at a magnification of 400 times. SPSS 11.5 statistical package was used.Results The β-APP was rising in 2h～6h and peaked in 4d～ ( 32.52±1.36)after cerebral ischemia,later β-APP was higher than that in control group.Conclusion The expression of β-APP is up-regulated after cerebral ischemia.It might aggravated cerebral ischemic injury.