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Effect of Losartan on the proliferation of vascular smooth muscle cell and expression of PDGF and c myc oncogene

Huang Shao-hu

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Abstract

Objective To investigate the mechanism of Losartan in treating hypertension and atherosclerosis.Methods The immunofluorescent quantitative skill and laser scanning confocal microscope (ACAS570) were employed to detect changes of the expression of PCNA, PDGF and c myc in cultured vascular smooth muscle cell effected through the Losartan .Results Under the observation of laser scanning confocal microscope (ACAS570), the fluorescent means of PCNA and c myc expression of VSMC in Losatan group were decreased compared with the control group, but that of PDGF had no changes.Conclusion Losartan possesses inhibitive effects on the proliferation of VSMC and the expression of c myc oncogene.This effect deals with the molecular mechanism of oncogene regulation.

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What this paper is about

Objective To investigate the mechanism of Losartan in treating hypertension and atherosclerosis.Methods The immunofluorescent quantitative skill and laser scanning confocal microscope (ACAS570) were employed to detect changes of the expression of PCNA, PDGF and c myc in cultured vascular smooth muscle cell effected through the Losartan .Results Under the observation of laser scanning confocal microscope (ACAS570), the fluorescent means of PCNA and c myc expression of VSMC in Losatan group were decreased compared with the control group, but that of PDGF had no changes.Conclusion Losartan possesses inhibitive effects on the proliferation of VSMC and the expression of c myc oncogene.This effect deals with the molecular mechanism of oncogene regulation.

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Available abstract

Objective To investigate the mechanism of Losartan in treating hypertension and atherosclerosis.Methods The immunofluorescent quantitative skill and laser scanning confocal microscope (ACAS570) were employed to detect changes of the expression of PCNA, PDGF and c myc in cultured vascular smooth muscle cell effected through the Losartan .Results Under the observation of laser scanning confocal microscope (ACAS570), the fluorescent means of PCNA and c myc expression of VSMC in Losatan group were decreased compared with the control group, but that of PDGF had no changes.Conclusion Losartan possesses inhibitive effects on the proliferation of VSMC and the expression of c myc oncogene.This effect deals with the molecular mechanism of oncogene regulation.

Key concepts: Losartan, Platelet-derived growth factor receptor, Oncogene, Vascular smooth muscle, Confocal, Cell growth, Cell, Proliferating cell nuclear antigen

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