Relationship between GDM offspring of red cell membrane insulin receptor and insulin resistance

Objective To investigate the relationship between gestational diabetes mellitus(GDM) offspring of red cell membrane insulin receptor and insulin resistance.Methods fasting blood glucose(FBG),fasting insulin(FINS),2 h postprandial blood glucose(2 hBG),postprandial 2 h Insulin(2 h INS),cholesterol(TC),glycerol 3 ester(TG),high density lipoprotein(HDL)、low density lipoprotein(LDL),and detection of high and low affinity of red cell membrane insulin receptor number(R1、R2) and affinity constants(K1、K2) were measured in32 cases of gestational diabetes their children,22 cases of normal pregnancy their children.calculated insulin resistance index(IRI).Results GDM group of children R1,R2 lower than the control group(P0.05);GDM group of children weight,BMI,FINS level higher than the control group(P0.05).Multiple stepwise regression analysis showed that factors into the regression equation BMI(t=3.362,P0.05),R1(t=-2.613,P0.05),R2(t=-2.541,P0.05),suggested that all factors affecting the GDM group of children the main risk factors for IR.Conclusion Gestational diabetes mellitus(GDM) offspring had insulin resistance,and the red cell membrane and reduce the number of insulin receptors,decreased affinity and obesity are closely related.