2009•Chinese Journal of ArteriosclerosisRequires access

Effects of Bezafibrate on the Expression of Caveolin-1 and the Proliferation of Smooth Muscle Cells Induced by Platelet-Derived Growth Factor

Da Wang

Abstract

Aim To observe the effects of bezafibrate on the expression of caveolin-1 and the proliferation of vascular smooth muscle cells(VSMC) induced by platelet-derived growth factor(PDGF) and investigate the mechanism of it.Methods VSMC were cultured in vitro,the proliferation of VSMC were obtained through thiazolyl blue colorimetric technique(MTT).The expression of caveolin-1 was assayed by Western Blotting.Results Compared with the control group,PDGF could increasingly induce the proliferation of VSMC(P0.01).Bezafibrate inhibited the proliferation of VSMC induced by PDGF in concentration-dependent manner(P0.01).Compared with the control group,PDGF could decrease caveolin-1 protein expression(P0.01).Bezafibrate increase the expression of caveolin-1 compared with the PDGF group(P0.01).With the increase of Bezafibrate's concentration,the expression of caveolin-1 could increase accordingly.Conclusion Bezafibrate can decrease the proliferation of VSMC induced by PDGF and increase the expression of caveolin-1 protein.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Bezafibrate, Platelet-derived growth factor receptor, Vascular smooth muscle, Platelet-derived growth factor, Growth factor, Internal medicine, Endocrinology, Cell growth