Effect of Ulinastatin on Lung Injury Induced by Liver Cold Ischemia-Reperfusion

Objective To investigate the effect of ulinastatin on lung injury induced by liver ischemia- reperfusion in rats. Methods Thirty healthy male SD rats were randomly divided into 3 groups. In control group( S group),only abdominal surgery was operated after blood vessels were dissociated. Cold ischemia / reperfusion was performed in Model control group( M group) without any treatment. In the ulinastatin( U group),the model was the same as M group,while UTI 100 000 U / kg was injected in the tail vein when the skin was cut. After 12 hours,the venous blood was obtained to detect the level of TNF- α and IL- 6. Lungs were removed to detect the level of MDA and SOD in tissue homogenate. The pathological changes of lung were evaluated by light microscopy. Results Compared with M group,the level of MDA,TNF- α and IL- 6 increased statistically in U group( P 0. 05),the level of SOD decreased statistically in U group( P 0. 05),and SOD in lung tissue increased( P 0. 05). Conclusion Ulinastatin can obviously attenuate lung injury after liver ischemia-reperfusion in rats.