2011•Shandong yiyaoRequires access
Expression and significance of CD_(117),CD_(34) in gastrointestinal stromal tumors
Gong Wei-da
Open publisher page 0 citations
Abstract
Objective To investigate the expression and significance of CD117 and CD34 in gastrointestinal stromal tumors(GIST).Methods We analyzed 88 cases of GIST pathological tissue samples and used Envision two-step immunohistochemical staining to detect the expression of CD117 and CD34 in these tissues.Results CD34 and CD117 positive expression rates were 78.4% and 95.4% in GIST,respectively.They were 87.9% and 94.0% in the low malignant potential of GIST,77.8% and 96.3% in the intermediate malignant potential of GIST,67.9% and 96.5% in the high malignant potential of GIST.Conclusions CD117 and CD34 overexpress in GIST.They are useful for the diagnosis of GIST,but they can not be used as indicators to determine the risk of GIST.