Effect Observation of Periocline Combined with Miconazole in Treatment of Denture Stomatitis

Objective:To compare the difference of drug effect,medication cycle and removal of fungi and putative pathogens,periocline(2% minocycline ointment) combined with 3% miconazole nitrate or single use of 3% miconazole nitrate were used in treatment of denture stomatitis,and the results were expected to provide reference for local medication in denture stomatitis.Methods:32 patients diagnosed as denture stomatitis were randomly divided into two groups with 16 patients in each group:experimental group(periocline combined with 3% miconazole nitrate group) and control group(3% miconazole nitrate group).Clinical indications and microbiology indexes of denture stomatitis patients were analyzed after 7 days and 14 days medication.Results:Clinical indications of two groups were both improved and showed significant difference between two groups(P0.05).Amount of Candida albicans and Streptococcus were obviously decreased after treatment,but there was no significant difference between two groups(P0.05).Amount of actinomycetes was obviously decreased in the experimental group(P0.01) after 14 days or one month' therapy,but the control group didn't show significant change.There was significant difference between two groups(P0.01).Conclusion:Periocline combined with 3% miconazole nitrate can effectively improve the cure rate of denture stomatitis,shorten treatment cycle and remove fungi and putative pathogens.