2003•Journal of Clinical Internal MedicineRequires access
Diagnostic value of brain natriuretic peptide in congestive heart failure
HE Zuoyou
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Abstract
Objective To evaluate diagnostic value of plasma brain natriuretic peptide(BNP) in patients with congestive heart failure(CHF).Methods 85 patients with acute dyspnea and whose B-type natriuretic peptide was measured with ELISA assay.The clinical diagnosis of congestive heart failure was adjudicated by two independent cardiologists,who were blinded to the results of the B-type natriuretic peptide assay.Thirty patients with normal ventricular function served as control group.Results The plasma BNP concentrations of CHF were significantly higher than that of non-CHF(P0.001 respectively),A plasma BNP concentration exceeding mean of the controls(x+1.96s) had a sensitivity of 96% and a specificity of 93% for diagnosis of congestive heart failure in patients with acute dyspnea.Conclusions Used in conjunction with other clinical information, measurement of B-type natriuretic peptide is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.