The relationship between brain natriuretic peptide and cardiac function and prognostic value of brain natriuretic peptide in congestive heart failure patients

Objective To investigate the relationship of brain natriuretic peptide(BNP) and cardiac function in congestive heart failure patients and the role of BNP in diagnosis,prognosis assessment in congestive heart failure. Methods Eighty-two congestive heart failure patients and 30 normal subjects were collected.Cardiac left ventricular ejection fraction was assessed by cardiac color Doppler ultrasound;plasma BNP levels was measured by fluorescence immunoassay;the patients were followed up for 2 years and survival analysis was performed.Results The plasma BNP levels in patients with heart failure is far higher than that in the normal healthy subjects(P 0.05),and BNP negatively related to cardiac function;survival analysis showed that BNP levels was closely related to two end-point events. Conclusion BNP levels and cardiac function is related,and BNP can be used for diagnosis and the prognosis assessment of congestive heart failure patients.