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2007•Medical Journal of National Defending Forces in Northwest ChinaRequires access

Early activation of T lymphocytes in patients with aplastic anemia

Shu-Fen Xu

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Abstract

Objective:To investigate the early activafion of T lymphocytes in patients with aplastic anemia(AA).Methods: Expressions of CD4,CD8 T lymphocytes and CD69 in these lymphocytes before and after culture with PHA in vitro were analyzed by two-color flow cytometry in 34 patients with aplastic anemia.Results: There was significantly lower expression of CD4+/CD8+ in aplastic anemia than normal controls.CD4+ and CD8+ lymphocytes partly expressed CD69 in severe AA patients,and only CD8+ cells expressed CD69 in chronic AA.After PHA stimulation in vitro,expression rates of CD69 in CD4+ and CD8+ cells increased quickly in AA patients and controls,but significantly higher in AA patients than that in controls.Conclusion: In AA patients there are abnormalities not only in quantity of T cell subsets,but also in function of T cells early activation,which might be associated with the pathogenesis of AA.

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Objective:To investigate the early activafion of T lymphocytes in patients with aplastic anemia(AA).Methods: Expressions of CD4,CD8 T lymphocytes and CD69 in these lymphocytes before and after culture with PHA in vitro were analyzed by two-color flow cytometry in 34 patients with aplastic anemia.Results: There was significantly lower expression of CD4+/CD8+ in aplastic anemia than normal controls.CD4+ and CD8+ lymphocytes partly expressed CD69 in severe AA patients,and only CD8+ cells expressed CD69 in chronic AA.After PHA stimulation in vitro,expression rates of CD69 in CD4+ and CD8+ cells increased quickly in AA patients and controls,but significantly higher in AA patients than that in controls.Conclusion: In AA patients there are abnormalities not only in quantity of T cell subsets,but also in function of T cells early activation,which might be associated with the pathogenesis of AA.

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Available abstract

Objective:To investigate the early activafion of T lymphocytes in patients with aplastic anemia(AA).Methods: Expressions of CD4,CD8 T lymphocytes and CD69 in these lymphocytes before and after culture with PHA in vitro were analyzed by two-color flow cytometry in 34 patients with aplastic anemia.Results: There was significantly lower expression of CD4+/CD8+ in aplastic anemia than normal controls.CD4+ and CD8+ lymphocytes partly expressed CD69 in severe AA patients,and only CD8+ cells expressed CD69 in chronic AA.After PHA stimulation in vitro,expression rates of CD69 in CD4+ and CD8+ cells increased quickly in AA patients and controls,but significantly higher in AA patients than that in controls.Conclusion: In AA patients there are abnormalities not only in quantity of T cell subsets,but also in function of T cells early activation,which might be associated with the pathogenesis of AA.

Key concepts: Aplastic anemia, CD69, CD8, Pathogenesis, Flow cytometry, Immunology, In vitro, T lymphocyte

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