An analysis on the significance of immunohistochemistry in the biopsy of small cell lung carcinoma

Objective To explore the diagnosis and differential diagnosis of biopsy specimens of small cell lung carcinoma via immunohistochemistry,considering the tissues acquired via pneumocentesis and bronchoscope are easily to be squeezed so much so that their structures become unclear, which lead to morphological overlaps between small cell lung carcinoma, poorly differentiated squamous carcinoma and lymphoma. Methods 46 patients who were received biopsy of pneumocentesis and bronchoscope were selected and were diagnosed of lung cancer both pathologically and morphologically.The diagnosed cancer tended to be small cell lung carcinoma.Each patients were received immunohistochemistry of CgA,Syn,Sclc,TTF-1, ki67,CK5/7,P63,34βE12 and LCA. Results Among the 46 patients diagnosed of lung cancer,biopsy specimens which tended to be small cell lung carcinoma were confirmed by immunohistochemistry: 43 patients were infected by small cell lung carcinoma,2 lower differentiated squamous carcinoma and 1 non-Hodgkin's lymphoma. Conclusion Immunohistochemistry is of great significance in the diagnosis and differential diagnosis of small cell lung carcinoma.