Catalytic Esterification of Carboxylic Acids and Alcohols by Sodium Bisulfate Monohydrate

The optimal reaction conditions for synthesizing isoamyl hexanoate,a flavoring substance,from isoamyl alcohol and hexanoic acid,catalyzed by sodium bisulfate monohydrate were determined.The optimum reaction conditions were as follows:molar ratio of hexanoic acid to isoamyl alcohol was 1:1.2,refluxing time was 60min,amount of catalyst was 0.5g(based on 0.2 mol hexanoic acid).The yield of isoamyl hexanoate reached 99.5%.Furthermore,four esters were also synthesized,using sodium bisulfate monohydrate as catalyst,with the yields of 98.3%~99.5%.