The effects of Montelukast on urinary leukotriene of henoch-schonleinpurpura in children

Objective By measuring the change of urinary LTE4 to discussed Montelukast treatment HSP effect.Methods Sixty patients were randomly divided into a control group of 30 patients treated with conventional therapy,in the recovery use of prednisone treatment in 2 weeks.The treatment group of acute period and recovery period continued to oral Montelukast for 2 weeks.Used ELISA for the detection of the two groups before and after treatment urinary LTE4 levels.Results On one week after treatment,the treatment group levels of LTE4 decreased more obviously(t = 28.860,P 0.05),But still higher than the normal(F = 46.268,P 0.05),and after two weeks,the treatment group and control group of LTE4 near normal(F = 2.796,P 0.05),compared to the control group decreased obviously(t = 4.777,P 0.05).Two groups of kidney damage without difference(χ2=0.218,P 0.05).Conclusion Leukotriene involved in the pathogenesis of HSP,Montelukast for the treatment of HSP can improve the curative effect,to improve the prognosis,small side effect.