Treatment of Acute Respiratory Distress Syndrome with Anisodamine and Noninvasive Positive Pressure Ventilation

Objective To compare the treatment efficacy of Anisodamine(654-2) combined with noninvasive positive pressure ventilation(654-2+NIPPV) with that of conventional mechanical ventilation(CMV) in patients with acute respiratory distress syndrome(ARDS) and evaluate the effect of 654-2+NIPPV on the treatment of ARDS.Methods Forty-two patients with ARDS caused by various disorders were randomly divided into 654-2+NIPPV group(21 cases) and CMV group(21cases).Patients in two groups were treated by 654-2+NIPPV through a facemask or CMV with endotracheal intubation respectively when disorders causing ARDS managed by medical therapy.Arterial blood gases were analyzed,and the rate of complication and outcome were observed.Results In 654-2+NIPPV group,8 patients were transformed into CMV for worsening condition and arterial blood gases.Mortality rate in 654-2+NIPPV group(28.6%) was similar to CMV group(33.3%)(P0.05).After 1 hour and 6 hours of ventilation,artery blood gas of patients of both two groups improved significantly and similarly. Duration of mechanical ventilation and hospital stay for patients receiving 654-2+NIPPV were significantly shorter than those in patients receiving CMV(P0.05).The complication rate in 654-2+NIPPV group was markedly lower than that in CMV group(0.05).Conclusion Clinical efficacy of 654-2+NIPPV was similar to CMV in selected patients with ARDS.Use of 654-2+NIPPV in patients with ARDS might reduce duration of mechanical ventilation and hospital stay,and decrease rate of complication.654-2+NIPPV might be the ventilatory support therapy of the first choice for the selected patients with ARDS.