Clinical observation of diazepam and Pethidine combined with misoprostol for analgesic artificial abortion

Objective To explore the clinical effect of diazepam and pethidine combined with misoprostol for analgesic artificial abortion.Methods Two hundred pregnant women who wanted to terminate early pregnancy in the Sixth People′s Hospital of Anyang,from September 2006 to February 2007,were randomly divided into two groups.The pregnant women in observation group were treated with 0.2-0.4 mg misoprostol by sublingual administration at thirty minutes before operation,the venous channel was opened with physiological saline,and 0.8 mg·kg-1 pethidine and 0.08 mg·kg-1 diazepam were injected into dropping pipette respectively,then after 3-5 min to start the operation.The conventional disinfection of cunnus,vagina and cervix was done in control group.The cervix was punctured and pumpback at the point of three and nine,when there was no blood,the cervix was injected 2.5 mL lidocaine needle respectively,then five minutes later to start operation.The effect of analgesic,degree of cervical looseness,artificial abortion syndrome,time of operation and volume of intraoperative hemorrhage were observed into two groups.Results The rate of aponia and degree of cervical looseness in observation group were significantly higher than these in control group(P0.01).And the rate of artificial abortion syndrome was significantly lower than that in control group(P0.01),The average volume of intraoperation hemorrhage and the average operation time were significantly lower than these in control group(P0.05).Conclusion The way of diazepam and pethidine combined with misoprostol for analgesic artificial abortion can reduce the volume of intraoperation hemorrhage,and shorten the operation time to achieve the purpose of analgesic artificial abortion with easy and low-cost.