2010•Zhongguo xin yao zazhiRequires access

Rationality of combination and proportion of cefotaxime/sulbactam in vitro

Ting Wang

Abstract

Resistance to cefotaxime of clinically isolated Gram-negative bacterial strains is extremely serious,and production of β-lactamases is one of the main mechanisms.Gram-negative bacterial strains mainly express TEM,CTX-M,and SHV type β-lactamases hydrolyzing cefotaxime.These β-lactamases can be effectively inhibited by sulbactam.The inhibition of cefotaxime/sulbactam(1∶1,2∶1) is stronger than cefotaxime/sulbactam(4∶1,8∶1).The antibacterial activity of cefotaxime/sulbactam(1∶1~8∶1) increased obviously in the antimicrobial tests in vitro in three regions(Beijing,Sichuan and Xi'an),and the effect of cefotaxime/sulbactam(1∶1,2∶1) was more suitable.The results showed that the cefotaxime/sulbactam combination is highly effective against cefotaxime-resistant Gram-negative bacterial strains,and cefotaxime/sulbactam(2∶1) is the reasonable proportion.

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Key concepts: Cefotaxime, Sulbactam, Microbiology, Chemistry, Antibiotics, Biology, Antibiotic resistance, Imipenem