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2013•Journal of Practical Traditional Chinese Internal MedicineRequires access

Duhuojisheng Decoction and Granule Osteoclast Effect on Rheumatoid Arthritis Model Rats Were Randomized Parallel Controlled Study

Jie Zhang

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Abstract

[Objective]Investigate Duhuojisheng Decoction on rheumatoid arthritis(RA) protective effect and mechanism of bone injury model of rats.[Methods]Establishment of type II collagen induced arthritis rat model of SD.60 SD rats were randomly divided into 4 groups: blank group,model group,leflunomide tablets group and Duhuo Jisheng Decoction granules group,were given by gavage for 6 weeks.To measure the expression of OPG,RANKL in serum of rats by in situ hybridization.[Results]The model group compared with the control group,the average optical density and the value of serum RANKL increased significantly,the average optical density value of the serum OPG was decreased significantly(P 0.05).[Conclusion] Duhuojisheng Decoction granules through the expression of serum OPG increased in rat model,to improve the ratio of OPG / RANKL,combined with the competitive inhibition of RANK and RANKL,thus effectively delay the RA bone erosion.

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[Objective]Investigate Duhuojisheng Decoction on rheumatoid arthritis(RA) protective effect and mechanism of bone injury model of rats.[Methods]Establishment of type II collagen induced arthritis rat model of SD.60 SD rats were randomly divided into 4 groups: blank group,model group,leflunomide tablets group and Duhuo Jisheng Decoction granules group,were given by gavage for 6 weeks.To measure the expression of OPG,RANKL in serum of rats by in situ hybridization.[Results]The model group compared with the control group,the average optical density and the value of serum RANKL increased significantly,the average optical density value of the serum OPG was decreased significantly(P 0.05).[Conclusion] Duhuojisheng Decoction granules through the expression of serum OPG increased in rat model,to improve the ratio of OPG / RANKL,combined with the competitive inhibition of RANK and RANKL,thus effectively delay the RA bone erosion.

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Available abstract

[Objective]Investigate Duhuojisheng Decoction on rheumatoid arthritis(RA) protective effect and mechanism of bone injury model of rats.[Methods]Establishment of type II collagen induced arthritis rat model of SD.60 SD rats were randomly divided into 4 groups: blank group,model group,leflunomide tablets group and Duhuo Jisheng Decoction granules group,were given by gavage for 6 weeks.To measure the expression of OPG,RANKL in serum of rats by in situ hybridization.[Results]The model group compared with the control group,the average optical density and the value of serum RANKL increased significantly,the average optical density value of the serum OPG was decreased significantly(P 0.05).[Conclusion] Duhuojisheng Decoction granules through the expression of serum OPG increased in rat model,to improve the ratio of OPG / RANKL,combined with the competitive inhibition of RANK and RANKL,thus effectively delay the RA bone erosion.

Key concepts: Medicine, Decoction, RANKL, Rheumatoid arthritis, Osteoclast, Leflunomide, Granule (geology), Internal medicine

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