The relationship between level of matrix metalloproteinase-1 and soluble CD40 ligand in patients with unstable angina

Objective To explore the role of expression and secretion of matrix metalloproteinase(MMP-1) mediated by CD40 ligand(CD40L) in pathogenesis in patient with unstable angina(UA) and to investigate the prognostic value and risk stratification of MMP-1 in UA.Methods Concentration of serum soluble CD40L and MMP-1 were measured by enzyme-linked immunosorbent assay in 64 UA patients,56 patients with stable angina(SA) and 40 controls.The 64 UA patients were divided into Braunwald's gradesⅠ,Ⅱ and Ⅲ.The correlations between MMP-1 and CD40L,and between MMP-1 levels and occurrence of cardiovascular events were analyzed.Results(1) Serum levels of MMP-1 were significantly higher in UA patients((55.53±18.25)μg/L) than in SA patents((31.38±13.64)μg/L,P0.01) and controls((11.58±9.83)μg/L,P0.05);serum levels of CD40L were significantly higher in UA patients((3.21±2.78)μg/L) than in SA patients((1.83±1.37)μg/L,P0.01) and controls((1.19±1.05)μg/L,P0.01).(2) MMP-1 level was positively correlated with CD40L level in UA patients(r=0.642,P0.01),MMP-1 was strongly correlated with CD40L.(3) The incidences of cardiovascular events were signicantly higher in patients with elevated MMP-1 levels than in patients with low levels of MMP-1.Conclusion (1) The blood levels of CD40L and MMP-1 were high in UA patients,suggesting that the elevated MMP-1 level may be mediated by CD40L in the rupture of coronary artery plaque.(2) The levels of MMP-1 were positively correlated with the occurrence of cardiovascular events in UA patients,suggesting that the level of MMP-1 is a highly sensitive and specific biochemical marker for assessing risk stratification and prognosis.