Significance of NF-κB p65 and cyclin D1 protein expression in Human Cervical Squamous cell carcinoma proliferation

[Objective] To evaluate the significance of expression of nuclear factor kappa B (NF-κB) p65 protein and cyclinD1 and their relationship with cervical carcinoma proliferation. [Methods] The expression of NF-κB p65 protein and cyclin D1 protein in 32 cases of Cervical Squamous cell tumor tissue and 30 cases of normal cervical tissue were studied immunohistochemically. [Results] None of the normal tissues exhibited NF-κBp65, In contrast, 22 of 32 Cervical Squamous cell carcinoma specimens were positive for p65 protein with a 68.7% positive rate. Cervical cancer tissue were 78.5 % expression for cyclin D1 protein, normal cervical tissue were 18.5% expression for cyclin D1 protein. The NF-κB p65 protein, cyclin D1 protein expression were correlated to the differentiation (P 0.05 ), The expression of NF-κB a65 was closely related with cyclin D1. [Conclusion] NF-κB p65 is a new oncogenic protein related to the cervical tumors. NF-κB up-regulates cyclin D1, then leads to tumor cell malignant proliferation and tumor occurrence.