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Significance and expression of NF-κB p65 and cyclin D1 protein in human cervical squamous cell carcinoma

Shulan Zhang

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Abstract

Objective: To evaluate the relationship between expression of nuclear factor kappa B (NF-κB) p65 protein and cyclin D1 and cervical carcinoma. Methods: The expressions of NF-κB p65 protein and cyclin D1 protein in 32 cases of cervical squamous cell carcinoma and 30 of normal cervical tissue were studied immunohistochemically. Results: No expression of NF-κB p65 was found in normal cervical tissue. In contrast, positive rate of p65 protein expression in cervical squamous cell carcinoma specimens was 68.75%. Positive rate of expression of cyclin D1 protein in cervical cancer tissue was 78.5 %, and 20.0% in normal cervical tissue.Conclusion: NF-κB up-regulates the expression of cyclin D1 , then leads to malignant proliferation of tumor cells and tumor occurrence.

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What this paper is about

Objective: To evaluate the relationship between expression of nuclear factor kappa B (NF-κB) p65 protein and cyclin D1 and cervical carcinoma. Methods: The expressions of NF-κB p65 protein and cyclin D1 protein in 32 cases of cervical squamous cell carcinoma and 30 of normal cervical tissue were studied immunohistochemically. Results: No expression of NF-κB p65 was found in normal cervical tissue. In contrast, positive rate of p65 protein expression in cervical squamous cell carcinoma specimens was 68.75%. Positive rate of expression of cyclin D1 protein in cervical cancer tissue was 78.5 %, and 20.0% in normal cervical tissue.Conclusion: NF-κB up-regulates the expression of cyclin D1 , then leads to malignant proliferation of tumor cells and tumor occurrence.

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Available abstract

Objective: To evaluate the relationship between expression of nuclear factor kappa B (NF-κB) p65 protein and cyclin D1 and cervical carcinoma. Methods: The expressions of NF-κB p65 protein and cyclin D1 protein in 32 cases of cervical squamous cell carcinoma and 30 of normal cervical tissue were studied immunohistochemically. Results: No expression of NF-κB p65 was found in normal cervical tissue. In contrast, positive rate of p65 protein expression in cervical squamous cell carcinoma specimens was 68.75%. Positive rate of expression of cyclin D1 protein in cervical cancer tissue was 78.5 %, and 20.0% in normal cervical tissue.Conclusion: NF-κB up-regulates the expression of cyclin D1 , then leads to malignant proliferation of tumor cells and tumor occurrence.

Key concepts: Cyclin D1, Cervical cancer, Immunohistochemistry, Cancer research, Cyclin D, NF-κB, Cyclin, Pathology

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Significance and expression of NF-κB p65 and cyclin D1 protein in human cervical squamous cell carcinoma — Research Paper | ScholarLens