2004•Chinese Remedies & ClinicsRequires access
The HBV-infection status of HBsAg-positive pregnant women and their newborns
Shuang Jie-y
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Abstract
Objective To learn the HBV-infection status of HBsAg-positive pregnant women and their newborns. Methods HBsAg was determined by enzyme-linked immunosorbent assay (ELISA); HBV-DNA was determined by nested PCR; PBMC HBV-DNA was determined by selected PCR; The newborns were intrauterinely infected if any one of the three markers showed positive. Results HBV-intrauterine infection rate was 43.1% for HBV-DNA and 30.8% for PBMC HBV DNA in HBsAg-positive pregnant women. HBV-intrauterine infection rate was 40.6%. HBV-intrauterine infection rate was 6.5% for HBsAg in serum, 19.5% for HBV DNA and 26.0% for PBMC HBV-DNA in newborns. Conclusion The detection of PBMC HBV is an important complement to the detectin of HBV-DNA in peripheral blood. It could be used for the aim of reflecting the the HBV-infection of HBsAg-positive pregnant women's newborns.