Clinical Observation of Mycophenolate Mofetil Combined with Low-dose Prednisone on Idiopathic Membranous Nephropathy

Objective To evaluate the efficacy and safety of mycophenolate mofetil(MMF) combined with low-dose prednisone as induction therapy for patients with idiopathic membranous nephropathy(IMN).Methods A total of 52 patients with IMN were randomly divided into two groups,CTX group 26 patients,received CTX 2.5 mg/(kg·d) and MMF group 26 patients,received MMF 1.5 g/(kg·d).Prednisone was gived at the dosage of(0.8-1.0) mg/(kg·d) in the morning per os in two groups.After 6-8 weeks,the dosage of prednisone were declined at the velocity of 5 mg per 4 weeks until stop it.The course of the treatment was one year.The curative effect indexes of 24 hours urine protein quantitation,plasma albumin(Alb),Scr and TG,and adverse reaction were compared between two groups.Results Compared to CTX group,the complete remission rate and partly remission rate were higher,the levels of 24 hours urine protein quantitation,Scr and TG were lower,Alb level was higher and adverse reaction rate was lower in MMF group(P0.05).Conclusion The effect of MMF combined with low-dose prednisone on idiopathic membranous nephropathy was good and adverse reaction rate was low.