Clinical application of coagulation and fibrinolysis indicators in patients with chronic obstructive pulmonary disease

Objective To analyze of the clinical application of coagulation and fibrinolysis indicators in chronic obstructive pulmonary disease(COPD) patients,and explore the relationship between fibrinolytic activity and the COPD disease.Methods 320 cases with COPD,including 170 cases in acute exacerbation stage and 150 cases in stable stage,were selected from January 2010 to June 2012 in respiratory department of our hospital.50 healthy normal subjects were selected.The plasma prothrombin time(PT),fibrinogen(FIB),activated partial thromboplastin time(APTT),plasma thrombin time(TT) and D-dimer(D-D) level were detected.Results(1) PT,FIB,and APTT obviously decreased,and TT and D-D level significantly increased in COPD group,compared with those in healthy control group(P0.01);(2) PT,FIB,APTT,TT and D-D levels in AECOPD group were significantly different with those in COPD group and control group(P0.01);(3) Compared with control group,FIB and DD level obviously changed(P0.01),PT and TT were significantly different(P0.05),and the value of APTT decreased slightly,with no significant difference(P0.05).Conclusion Monitoring of PT,APTT,TT,FIB and D-D level in the patients with COPD,provides the reliable basis for hypercoagulability and primary and secondary fibrinolytic hyperfunction in COPD patients,and provides an objective theoretical basis for necessary intervention measures on early prevention of thrombosis.