Risk factors for intelligence quotient of children with focal seizures

Objective To investigate the risk factors of IQ in children with focal seizures.Methods IQ of 89 children were tested from 2005 to 2009.The type and epileptogenic area of the epilepsy were determined according to the results of symptoms,EEG,CT or MR.Multivariate Logistic regression analysis were used to determine risk factors of IQ.Results IQ testing showed that 58.4%(52/89)of children with focal seizures epilepsy were IQ dysfunction.Multivariate logistic regression analysis find seizure frequency(P=0.022;odds ratio,OR=3.807;95% confidence interval,95%CI=1.215-11.926)MRI or CT outcome(P=0.010;OR=5.035;95%CI=1.467-17.286)and drugs numbers(P0.01;OR=9.105;95%CI=2.639-31.408)were the independent risk factors for IQ of children with focal seizures.Age at epilepsy onset,epilepsy duration,seizure types,epileptogenic area were not independent risk factors for IQ.Conclusion IQ of children with focal seizures epilepsy are easily impaired.High seizure frequency,imaging abnormalities,more numbers of drugs indicate IQ more easily impaired of children with focal seizures.We should take the necessary measures to slow down the process of IQ decline according to the factors.