Study on the Relation between Helicobacter Pylori Infection and Gastric Metaplasia in the Duodenum in the Duodenal Ulcer Patients

Objective To study on the relation between Helicobacter pylori (Hp) infection and gastric metaplasia in the duodenum(DGM) in the duodenal ulcer(DU) patients to elucidate the pathogenesis of DU.Methods One hundred and twenty-one patients were examined by endoscopy, pathology and Hp infection test.Results The detection rates of Hp in stomach and in duodenal bulb were much higher in patients with DU(90 4%, 40 4%) than those in patients without DU(60 9%, 2 9%, both P0 001).The prevalence of DGM was much higher in the DU patients(92 3%) than that in the non-DU patients(42 0%,P0 001),and the extent of DGM was also more serious in the former than in the latter(P0 001).DGM was identified in 73 0% of patients with Hp in stomach, and in 37 5% of patients without Hp(P0.001). The extent of DGM was significantly greater in the patients with Hp positive in stomach than that in the patients with Hp negative.47 2% of Hp positive patients had DGM(++) and more serious DGM compared with the Hp negative patients(21 9%,P0 05). In duodenum, Hp was mostly detected on areas of DGM, and Hp prevalence showed an increasing trend with the extent of DGM increasing.Conclusions Hp infection,especially in duodenum and DGM may be two major risk factors influencing appearance and development of DU. There is a significant association between Hp infection and DGM.