Expression and Significance of E-cadherin and N-cadherin in Breast Carcinoma

To detect the EMT phenotype molecule E-cadherin and N-cadherin protein expressions in invasive ductal breast carcinoma,and to investigate the correlation between EMT and breast tumor-genesis and histological grade.E-cadherin and N-cadherin protein expressions were determined by immunohistochemistry envision method in 70 cases of breast cancer and 20 cases of cancer adjacent normal tissue microarray.E-cadherin expression was significantly reduced in invasive ductal breast carcinoma,Simultaneously,N-cadherin expression was significantly increased,and a significant correlation was observed between Ecadherin and N-cadherin,(r=0.405,P0.05).Ranging from High,medium to low breast cancer differentiation,E-cadherin positive expression was gradually increased,while N-cadherin expression was gradually decreased.EMT in breast cancer cell was involved in breast tumor-genesis and associated with the malignancy of breast carcinoma.