Correlation analysis on the pregnancy outcome and cycles of intrauterine insemination with husband sperm

Objective To explore the correlation between the cycles of intrauterine insemination (IUI) with husband sperm and the pregnancy outcome. Methods A total of 2 196 IUI cycles were analyzed retrospectively. The relationship between the number of cycles of IUI and pregnancy rate was analyzed. Results 1 625 infertile couples were treated with 2 196 cycles of IUI. 329 cases were found with pregnancy. The pregnancy rate (PR) was 15% per cycle and 20.2% per couple. The clinical PR for the first, second, third and fourth cycle were 15.2%, 14.9%, 12.9% and 0.0%, respectively, with no statistically significant differences (P0.05). The cycle PR for the one cycle, two cycle, three cycle, four cycle were 19.7%, 10.1%, 8.9%, 6.3%, respectively, with statistically significant difference between the one, two, three cycle. The cumulative pregnancy rates for the four groups were 19.7%, 20.2%, 26.7%, 25%, respectively, with no statistically significant differences (P0.05). Conclusion Adding IUI cycles properly could increase the clinical pregnancy rate.