Antifungal Susceptibility Test of 506 Clinical Candida Albicans Isolates to Fluconazole and Itraconazole In Vitro

Objective To investigate the susceptibility of C.albicans isolates to fluconazole and itraconazole in vitro. Methods C.albicans was collected and identified from clinical isolates.M27-A2 Broth microdilution method,recommended by the Clinical and Laboratory Standards Institute(CLSI),was used to assess the susceptibility of clinical C.albicans to fluconazole and itraconazole.Results A total of 506 clinical C. albicans isolates were collected.Three of the isolates were resistant to fluconazole,and one was susceptible -dose dependent to fluconazole.The resistant rate was 0.59%.Eighteen isolates were resistant to itraconazole, and 269 were susceptible-dose dependent to itraconazole.The resistant rate was 3.56%.There was one isolates presenting cross-resistant to both fluconazole and itraconazole.Conclusion Some of the clinical C.albicans isolates do resist or cross-resist to antifungal azoles.The resistant rate of Itraconazole is higher than fluconazole.