2010•Dalian Yike Daxue xuebaoRequires access
Observing the susceptibility of Candida albicans to fluconazole terbinafine and itraconazole and nystatine by m27 - a microdilution method.
Song XiaoJing, Dong Yan, Hong Zhang, Zheng TongJiao
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Abstract
[Objective] To compare the susceptibility of candida albicans cultured with fluconazole,terbinafine,itraconazole and nystatine.[Methods] M27-A Microdilution Method based on NCCCLS was used to determine the susceptibility of 38 candida albicans isolates cultured with fluconazole,terbinafine,itraconazole and nystatine.[Results] Four fluconazole-resistance isolates,34 susceptible isolates,5 itraconazole-resistance isolates,33 susceptible isolates,15 terbinafine-resistance isolates and 23 susceptible isolates were detected from 38 clinical candida albicans isolates.[Conclusion] The susceptibility of candida albicans to fluconazole is the highest in the 4 drugs,but the resistance to fluconazole and cross-resistance between fluconazole and itraconazole are found in this study.