Therapeutic efficacy of Ganshuang granules in treatment of hepatic fibrosis

Objective To observe the therapeutic efficacy of Ganshuang granules in the treatment of hepatic fibrosis.Methods Sixty- eight patients with cirrhosis due to chronic hepatitis B(CHB) were divided into experimental group(n = 34) and control group(n = 34).Both groups received adefovir dipivoxil for 6 months,and the experimental group received Ganshuang granules additionally for 24 weeks.After treatment,the changes in hepatic fibrosis indices including hyaluronic acid(HA),laminin(LN),collagen Ⅳ(C Ⅳ),and precollagen Ⅲ(PC Ⅲ),as well as liver stiffness value were evaluated by paired t test.Results In the experimental group,the serum levels of HA,LN,C Ⅳ,and PC Ⅲ were significantly decreased by 37.5%,34.2%,35.4%,and 39.9%,respectively(t = 2.238,2.151,2.148,and 2.198,P 0.05 for all),and the liver stiffness value was significantly cut by 40.6%(t = 2.189,P 0.05).However,the control group showed no significant changes in these indices.Conclusion For patients with cirrhosis due to CHB,Ganshuang granules can effectively reduce serum markers of hepatic fibrosis and liver stiffness value and have a good therapeutic efficacy in the treatment of hepatic fibrosis.