2010•jOURNAL OF southwest University for NationalitiesRequires access

Dynamic expression of TGF-β_1 in CCI_4 induced hepatic fibrosis in rats

Xiaoqin Zhang

Abstract

Objective:To study the changes and significance of TGF-β1 in experimental hepatic fibrosis.Methods: Liver fibrosis in SD rats is induced by subcutaneous injection of 40%CC14 in peanut oil.Five rats are sacrificed each time 3,5,7,9,13 weeks after administration of CC14 and 1iver tissues are taken for pathological examination,and five norma1 rats are sacrificed as control each time.Expression of TGF-β1 protein is measured by immunohistochemistry.Result: In the process of the hepatic fibrosis induced by CC14 in rat,the expression of TGF-β1 is elevated from the early stage significantly,and more expression of TGF-β1 is observed in the late stage.Conclusion: The expression of TGF-β1 is correlated with the process of hepatic fibrosis positively.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Immunohistochemistry, Hepatic fibrosis, Subcutaneous injection, Fibrosis, Pathological, Transforming growth factor, Stage (stratigraphy), Medicine