The impact of a gonadotropin-releasing hormone antagonist on the outcome of PCOS patients who underwent in vitro fertilization

Objective:To investigate the effect of the protocol of gonadotropin releasing hormone antagonist on the outcome of PCOS patients who underwent in vitro fertilization.Methods: PCOS patient who subjected to IVF between April 2006 and July 2006 were divided randomly into two group:the study group:eighteen patients with PCOS were subjected to a protocol of gonadotropin-releasing hormone antagonist.The control group:twenty-four patient with pcos were subjected to a long protocol of gonadotropin-releasing hormone agonist.To record the doses of gonadotrophins(HMG and/or rFSH),the during of administration,the number of retrieved oocyte,the ratio of fertilization,the ratio of cleavage,the thick of endometrium and the profile of serum E2 on the day of HCG administration,Cycle cancellation rate,Implantation rate of embryo,Pregnantion rate and the incidence rate of OHSS.Results: The two groups were similar with respect to the doses of gonadotrophins(HMG and/or rFSH),the during of administration,the number of oocyte retrieval,the ratio of fertilization,the ratio of cleavage,and the incidence rate of OHSS.Significant differences(P0.05) were found regarding pregnant rate,implantation rate of embryo,and the profile of serum E2 by analyzing statistically(Student′s t-test and χ2-test).Conclusion: We demonstrated that GnRH antagonist administration in PCOS patients undergoing IVF did not impact the development of follicle and alter the oocyte competence.The pregnancy rate and the implantation rate were increased,most likely,Owing to increasing endometrial receptivity.in addition,the profile of serum E2 was reduced,which decreased the incidence of OHSS.These result demonstrated the high performance and safety of this drug on controlled ovarian stimulation protocol.The protocol was optimal