The Therapeutic Efficacy of Lamivudine Combined with Adefovir Dipivoxil in Hepatitis B Liver Cirrhosis

Objective To investigate clinical efficacy,safety and drug resistance of Lamivudine combined with Aadefovir dipivoxil in hepatitis B liver cirrhosis.Methods Seventy-eight cases of hepatitis B were randomly divided into two groups with liver cirrhosis divided into 31 cases of treatment group.Lamivudine combined with oral Adefovir dipivoxil treatment of one of the 24~48 weeks.And with the control group,47 cases of Lamivudine alone,compared to Adefovir dipivoxil.Treatment kept for 24~48 weeks.Results In treatment group after 12 and 24 months of treatment virological response and biochemical analysis response were significantly different from that in control group(P0.01).No serious adverse reactions was found.Conclusion Lamivudine combined with Adefovir dipivoxil treatment off hepatitis B cirrhosis shows no resistance.Since the complementary roles,patients could receive a long-term drugs with stable condition.