Clinical Research of the Co-treatment of Adefovir Dipivoxil Combined with Lamivudine on Hepatitis B Cirrhosis

Objective To investigate the co-treatment of adefovir dipivoxil combined with lamivudine of hepatitis B cirrhosis efficacy,safety and tolerability.Methods Ninety patients with liver cirrhosis were randomly divided into 3 groups.A:combined treatment group,30 cases of oral lamivudine plus adefovir dipivoxil each one;B:lamivudine treatment group,30 patients;C:single treatment with adefovir dipivoxil 30 patients.All the patients were treated 48 to 96 weeks.Results The treatment group was 12,24 months,virologic response,treatment for 12 months,biochemical response compared with the control group there were significant differences(all P0.01),no serious adverse events.Conclusion Lamivudine and adefovir dipivoxil treatment of hepatitis B cirrhosis,drug resistance is not easy,and can play complementary roles in long-term stable disease patients.