Study Early Use Noninvasive Positive Pressure Ventilation in Acute Exacerbations of COPD Complicating Respiratory Failure

Objective To estimate the clinical value of early use noninvasive positive pressure ventilation(NIPPV)in acute exacerbations of COPD(AECOPD)complicating respiratory failure.Methods 60 COPD cases with hypercapnia were involved in the study.The patients were randomized into two groups(BiPAP group and standard therapy group).Standard therapy group was control group.All the cases were recorded blood gas analysis and clinical syndrome change at beginning and end.Results The PaCO2 was significantly decreased in BiPAP group at end of the trial,meanwhile,the PaO2 and pH were significantly increased.Compared with BiPAP group,the Standard therapy group also have better effect on blood gas change,but the in-hospital days of BiPAP group had been shortened,and BiPAP group also lowered the rate of endotracheal intubation.Conclusion The application of NIPPV can improve clinical syndrome and lower the rate of endotracheal intubation and the lenth of hospital stay in COPD exacerbations patients,it may be added to coven-tional medical therapy in exacerbated chronic obstructive pulmonary disease.