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2004•Parenteral & Enteral NutritionRequires access

The effects of enteral immunonutrition on immunological function and inflammatory responses in severe scalded rats

Guo Guang

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Abstract

Objectives:To investigate the effects of enteral immunonutrition (Stresson) on immunological function and inflammatory responses in severe scalded rats. Methods:Sixty four SD rats inflicted by 30% TBSA Ⅲ degree scalds were randomly divided into enteral immunonutrition(EIN) and enteral nutrition (EN) groups.Animals of both groups were fed isocaloric enteral nutrition. Lymphocyte subsets, serum levels of immunoglobulins,endotoxin,IL 6,TNF α were determined on the 1st,4th,7th and 10th day postburn. Results:CD3 + ,CD4 + ,CD4 + /CD8 + in EIN group were higher( P 0.05 or P 0.01)than those in EN group on the 7th and 10th days postburn. The serum concentrations of IL 6, endotoxin and TNF α were singnificantly lower in EIN group than those in EN group( P 0.05 or P 0.01). Conclusions: Enteral immunonutrition could not only ameliorate the damage of immunological function, but also reduce inflammatory responses in serere scalded vaes.

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Objectives:To investigate the effects of enteral immunonutrition (Stresson) on immunological function and inflammatory responses in severe scalded rats. Methods:Sixty four SD rats inflicted by 30% TBSA Ⅲ degree scalds were randomly divided into enteral immunonutrition(EIN) and enteral nutrition (EN) groups.Animals of both groups were fed isocaloric enteral nutrition. Lymphocyte subsets, serum levels of immunoglobulins,endotoxin,IL 6,TNF α were determined on the 1st,4th,7th and 10th day postburn. Results:CD3 + ,CD4 + ,CD4 + /CD8 + in EIN group were higher( P 0.05 or P 0.01)than those in EN group on the 7th and 10th days postburn. The serum concentrations of IL 6, endotoxin and TNF α were singnificantly lower in EIN group than those in EN group( P 0.05 or P 0.01). Conclusions: Enteral immunonutrition could not only ameliorate the damage of immunological function, but also reduce inflammatory responses in serere scalded vaes.

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Available abstract

Objectives:To investigate the effects of enteral immunonutrition (Stresson) on immunological function and inflammatory responses in severe scalded rats. Methods:Sixty four SD rats inflicted by 30% TBSA Ⅲ degree scalds were randomly divided into enteral immunonutrition(EIN) and enteral nutrition (EN) groups.Animals of both groups were fed isocaloric enteral nutrition. Lymphocyte subsets, serum levels of immunoglobulins,endotoxin,IL 6,TNF α were determined on the 1st,4th,7th and 10th day postburn. Results:CD3 + ,CD4 + ,CD4 + /CD8 + in EIN group were higher( P 0.05 or P 0.01)than those in EN group on the 7th and 10th days postburn. The serum concentrations of IL 6, endotoxin and TNF α were singnificantly lower in EIN group than those in EN group( P 0.05 or P 0.01). Conclusions: Enteral immunonutrition could not only ameliorate the damage of immunological function, but also reduce inflammatory responses in serere scalded vaes.

Key concepts: Medicine, Enteral administration, Parenteral nutrition, Gastroenterology, CD8, Internal medicine, Lymphocyte, Immunologic function

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