Application of carotid atherosclerotic plaque and hs-CRP level in prediction and determination of cerebral infarction

Objective To observe the association of carotid atherosclerotic plaque and serum high-sensitivity C-reactive protein( hs-CRP) level with cerebral infarction and to investigate the clinical application value that combined detections of carotid color ultrasonography and serum hs-CRP in patients with cerebral infarction. Methods Eighty-three cases of patients with anterior circulation infarct as the experiment group and 50 cases of healthy volunteers as the control group were selected. Carotid color ultrasonography was employed to detect the carotid plaque and intima-media thickness( IMT), and immunoturbidimetry was used to detect the levels of serum hs-CRP,and then the relationship between serum hs-CRP and IMT in different degrees of patients with cerebral infarction was analyzed. Results The positive incidence of carotid plaque,levels of IMT and serum hs-CRP in the experiment group were higher than those of the control group; the IMT and serum hs-CRP levels,incidence of cerebral infarction at the same side of infarction side in unstable plaque were higher than those in stable plaque; significant difference was found( all P 0. 05). The serum hs-CRP was positively correlated with IMT,and there was positive correlation between serum hs-CRP and serious degree of cerebral infarction patients( r = 0. 67, r = 0. 58; all P 0. 05). Conclusions Carotid color ultrasonography displays that there is significant correlation between carotid atherosclerotic stable plaque and cerebral infarction. The level of serum hs-CRP not only assesses carotid unstable plaque,but also reflects serious degree of cerebral infarction. Combined detections of carotid color ultrasonography and serum hs-CRP level can help the prediction and determination of cerebral infarction.