The value of HbA1c in the screening of gestational diabetes mellitus

Objective To investigate the diagnosis value of HbA1 cfor gestational diabetes mellitus(GDM).Methods 411 pregnant women were recruited in the antenatal clinic of Tongling Maternal and Child Health Care Centre from January 2014 to November 2014.OGTT was processed during 24 to 28weeks of gestation,and HbA1 c was detected at the same time.According to the OGTT results,the pregnant women were divided into 3groups:GDM group,impaired glucose tolerance group and normal glucose tolerance group.To compare the differences of OGTT results and HbA1 clevels among 3groups,and to assess the value of HbA1 cin the screening of GDM.ResultsThe levels of fasting plasma glucose(FPG),1hplasma glucose,2hplasma glucose and HbA1 cin GDM group were higher than the other two groups,and the differences were statistically significant(P0.05).ROC curve showed that the optimal diagnostic cut off value of HbA1 cwas 5.75%,the sensitivity,specificity,positive predictive value and negative predictive value were 83.4%,74.8%,67.7%,and 89.2%,respectively.Conclusion HbA1 chas important clinical value in the screening of GDM,which can reduce the rate of missed diagnosis.